Detalhe da pesquisa
1.
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.
Immunity
; 56(9): 2121-2136.e6, 2023 09 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37659412
2.
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Nature
; 586(7827): 113-119, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32707573
3.
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads.
Bioorg Med Chem Lett
; 96: 129489, 2023 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37770002
4.
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit.
J Infect Dis
; 224(Supplement_1): S1-S21, 2021 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34111271
5.
Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.
J Virol
; 94(11)2020 05 18.
Artigo
Inglês
| MEDLINE | ID: mdl-32188728
6.
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors.
Molecules
; 26(19)2021 Sep 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34641337
7.
Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors.
Biochemistry
; 58(44): 4424-4435, 2019 11 05.
Artigo
Inglês
| MEDLINE | ID: mdl-31549827
8.
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
Bioorg Med Chem Lett
; 28(15): 2605-2610, 2018 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29970308
9.
Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus.
J Mol Recognit
; 30(11)2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28608547
10.
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.
Bioorg Med Chem Lett
; 27(11): 2432-2438, 2017 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28427814
11.
X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions.
J Biol Chem
; 290(42): 25293-306, 2015 Oct 16.
Artigo
Inglês
| MEDLINE | ID: mdl-26296883
12.
Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.
J Biol Chem
; 290(32): 19403-22, 2015 Aug 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26055715
13.
Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.
J Virol
; 89(9): 4907-17, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-25694594
14.
Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme.
Arch Biochem Biophys
; 612: 35-45, 2016 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27756680
15.
Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.
J Virol
; 88(21): 12511-27, 2014 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-25142582
16.
Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance.
J Virol
; 88(20): 11886-98, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25100843
17.
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.
J Virol
; 88(20): 11825-33, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25100850
18.
Structure-based design, synthesis and biological evaluation of novel ß-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.
Bioorg Med Chem Lett
; 25(3): 668-72, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25537272
19.
X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design.
Bioorg Med Chem Lett
; 25(22): 5072-7, 2015 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26592814
20.
Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4--The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS).
Bioorg Med Chem
; 23(17): 6036-48, 2015 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26190463